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Human obesity development did not establish statistically significant weight-loss efficacy in the largest reported placebo-controlled trial, and the available clinical record is insufficient to establish comprehensive safety, particularly across material forms, formulations, routes, and long-term exposure

doi: 10.2174/1381612823666170220163219

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Also, its deficiency can result in high levels of homocysteine in the blood which may have direct effects on the neurotransmitters implicated in depression