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Because certain procedures can entail literally cutting out part of your small intestine, nutrients get dumped further down, causing a big GLP-1 ileal brake response

doi: 10.3390/jpm12030458 67 DoanH

The resulting diminishment of Hes1 expression and other Notch effectors compromises the sphere-forming ability of CSCs and their capacity to maintain the undifferentiated state (72, 73)