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Long considered a superfood for its various health-promoting benefits, flaxseed has been shown to improve several cardiometabolic biomarkers, increase antioxidant protection, relieve occasional constipation and help with quality of life by improving mental fatigue

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Among the overlapping downregulated genes were Pparg and Cebpa , master regulators of fat cell metabolism, insulin sensitivity and adipogenesis, and Ppargc1b , a transcriptional coactivator for PPARs 31

Modulation of GABAergic neurotransmission, including receptor expression, by probiotics following ES-induced depression has been shown [72, 84]

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