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Clinical trials in Alzheimers disease Alzheimers disease is where the 2025 data forced the largest revision, and where the contrast between observational promise and trial outcome is sharpest

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What they did: A two-phase study, first in a dish with human endothelial cells (HUVECs), then in a live rat with an ischemic limb (= they closed off the artery so that no blood reached the leg)