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In these neurons, the presence of GLP-1 signifies mechanical distension in the gut, signalling the neurons to facilitate increases in gastric pressure which is needed for normal digestion and may explain other gastrointestinal side-effects such as diarrhea

Key highlights Wegovy (semaglutide) is a GLP-1 receptor agonist and Zepbound (tirzepatide) is a GLP-1/GIP receptor agonist