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Peptides are often used by our bodies as chemical messengers

doctors suspected endotoxin contamination or supraphysiological glutathione dose in a nutritionally compromised host

These stressors can damage cellular components, trigger ROS production, and induce ferroptosis by overwhelming antioxidant defenses mediated by GPX4, as well as disrupting the cysteine-glutathione axis via System Xc- (145)

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Very recently, it has been also reported the subcellular localization of GSNO in pea leaves by electron microscopy immunocytochemistry and immunogold particles were clearly visible in cytosol, chloroplasts, mitochondria, and peroxisomes (Barroso et al., 2013)