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Int J Physiol, Pathophysiol Pharmacol 11(3):6475 Li W, Huang X, Deng C, Zhang B, Qian K, He M, Sun T (2021) Olanzapine induces inflammation and immune response via activating ER stress in the rat prefrontal cortex
Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases
doi: 10.1007/s40618-017-0693-z 60 SchomburgL
Supplementation requires nuance
A prospective randomized controlled study evaluating the potential preventive effect of L-carnosine on acute oxaliplatin neurotoxicity in patients with colorectal cancer enrolled 65 patients and showed that the levels or activities of NFB (27%) and TNF- (36.6%) were significantly decreased in the group receiving the FOLFOX-6 regimen (oxaliplatin, 5FU, and leucovorin) with daily oral L-carnosine (500 mg), while L-carnosine as a supplement for patients with CIPN alleviated neuropathic symptoms by decreasing oxidative stress (Nrf-2 and NF-B pathways) and apoptosis (caspase-3 activity) [144]
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