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The findings obtained from the SMART collaborative meta-analysis (SGLT2 Inhibitor Meta-Analysis Cardio-Renal Trialists), designed to evaluate the impact of SGLT2is on cardiovascular and renal outcomes based on the concomitant use or non-use of GLP1-RAs, included 12 controlled clinical trials with 73,238 participants, of whom 3065 (4.2%) received GLP1-RAs

Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: a randomised, controlled, phase 2 trial

But for a large number of patients, the medications fall short, fail entirely, or come with side effects that make long-term use impossible

R., Pahl, M