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When exposure remains ongoing, inflammatory signaling does not resolve, regardless of supplementation or supportive therapies
The scaffold-based 3D models mentioned above are considered static systems, as they replicate the structural support of the ECM but do not emulate the hemodynamic forces that ECs are exposed in vivo [225]
Even for patients with malabsorption diseases (conditions where the gut doesnt absorb nutrients properly), like Acrodermatitis Enteropathica, taking oral supplements is still the usual therapeutic approach
Knockout-transgenic mouse model of sickle cell disease
& Vanden Berghe, T
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