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topoisomerase I inhibitor (TOPO1i) ED04 was coupled to a cysteine site on SI-B001 via a novel cleavable AC linker, generating a novel BsADC, named BL-B01D1, with a reported average DAR of approximately 8

When taken in excess of 3000 micrograms retinol equivalents, vitamin A can cause birth defects

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Astrocytes release free fatty acids (FFAs) from lipid droplets, and the released fatty acids enter the mitochondria and bind to carnitine to form LCACs, the accumulation of which leads to mitochondrial dysfunction in astrocytes and exacerbates neuronal damage [115]

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