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It is not blocking a pathway, it is speeding up a repair that would otherwise take much longer or stall entirely
Most published KLOW research protocols span 816 weeks with gradual titration
Our data suggest that hypermethylation of the 25-hydroxylases, 1--hydroxylase enzymes, and the vitamin D receptor promoter, accompanied by hypomethylation of CYP24A1, leads to impaired expression and possibly a predisposition to VD deficiency/inadequacy
Depending on the individual, they start working within 48 to 72 hours of the first dose, but they might take three months to completely correct a B12 deficiency
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