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[3] For confirmed deficiency with neurological involvement: 1 mg IM on alternate days until no further improvement, then 1 mg every two months urgent initiation is essential to prevent irreversible nerve damage

In the brain, they observed changes in the expression of genes associated with mitochondrial and neuronal structure, mitochondrial respiration, and neurodevelopmental processes, with key genes (e.g., fkbp5 and ucp2 ) correlating with the response to SSRIs and neurodevelopment

SASP (senescence-associated secretory phenotype) results revealed that FOXO4-DRI downregulates the levels of IL-1 , IL-6 , IL-8 , and TNF- (Figure 4H)

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