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This approach was chosen deliberately, given the current scarcity of randomized controlled trials and the limited number of clinical studies specifically addressing GLP-1RAs in PsA

Do not use it if you have had a myocardial infarction or have established coronary artery disease

Notably, adipocytes from Gcgr / mice failed to induce lipolysis upon G49 treatment, suggesting a lipolytic action, at least in part, via GCGR as it will be discussed below

Studies show that GLP-1 agonists can be safe long-term under medical supervision

While prescription weight loss medications have been on the market for decades, such as phentermine, the newer GLP-1s, including Ozempic (used off-label for weight loss) and Wegovy, have been generally shown to be more effective than previous treatments