No regulatory authority Health Canada, the FDA, the EMA, the TGA, or any equivalent has cleared ipamorelin for therapeutic use in humans or animals
The current US presidential administrations push for a most-favored-nation pricing model, effectively benchmarking US drug prices to international levels, has brought Novo and Lillys GLP-1 drugs under tighter pricing scrutiny
A newer GLP-1 receptor agonist, tirzepatide, demonstrates weight loss as high as 20% change in body weight compared with 3% in the placebo group in a RCT
A combination of semaglutide and metformin also promotes better glycemic control
In the SURMOUNT-1 trial with 2,539 participants, patients taking 15 mg tirzepatide weekly (combined with diet and exercise) lost an average of 20.9% of their body weight over 72 weeks