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doi: 10.1186/ar4174 7 BullockJRizviSAASalehAMAhmedSSDoDPAnsariRAet al
Patients should be educated about red flag symptoms requiring immediate medical attention, including severe persistent abdominal pain (especially if radiating to the back, suggesting possible pancreatitis), right upper quadrant pain with fever or jaundice (potential gallbladder disease), inability to keep fluids down for more than 24 hours, syncope, chest pain, or difficulty breathing
Although N-acetylcysteine (NAC) directly influences the pool of extracellular cystine and intracellular cysteine via a series of plasmatic redox reactions, in order to be effective, intracellular cysteine precursors must be designed to enter erythrocytes rapidly and use high activity enzymes within erythrocytes to liberate cysteine (Whillier et al., 2009