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Numbness or tingling in hands and feet Peripheral nerve changes are a more serious sign of prolonged deficiency

doi:10.1001/jama.2013.280490

A 2012 study in the Journal of Peptide Science compared copper-bound and copper-free forms of the tripeptide in skin stem-cell-recovery models, providing a direct fragment-versus-complex contrast useful for interpreting the broader literature (PMID 23019153)

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