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Since 2015, large-scale cardiovascular outcome trials (CVOTs) have demonstrated that sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly reduce the risk of major adverse cardiovascular events, cardiovascular mortality, and heart failure hospitalization in patients with T2DM and established cardiovascular disease or high-risk profiles

An increased MMPs/tissue inhibitor MMPs (TIMPs) ratio is more strongly associated with tissue response to LPS-linked injury than with the acute-phase reaction (242, 243)

Injection site does not meaningfully affect timing-dependent GH response

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