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Clinical trials have focused on people living with obesity, early research shows it could, if licensed, be used for conditions like type 2 diabetes and fatty liver disease
It is the tenth leading cause of death and is projected to become the fifth most common cause of death by 2050
In one study, exogenous administration of combined GLP-1R/Y2-R agonists partially mimicked the positive effects of bariatric surgery but did not lead to the anticipated overall metabolic improvements 10 suggesting other pathways are also involved
The result is prolonged biological activity and sustained receptor activation
60% of insurance appeals succeed, but 88% of people never try
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