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Because B12 is water-soluble, the NIH Office of Dietary Supplements notes that no tolerable upper intake level has been established excess B12 is excreted by the body rather than accumulating to toxic levels
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The compound discussed here is investigational, and the published research on it is largely preclinical
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Both were removed from FDA 503A Category 2 on April 22, 2026, but neither is on Category 1 either
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