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As a modified version of the naturally occurring GLP-1 hormone, semaglutide has a 94% amino acid sequence homology to human GLP-1 but includes strategic modifications that extend its half-life to approximately one week, enabling once-weekly dosing
Subsequent experimental models examined its pathway-level activity in connective tissue and vascular-related research frameworks
doi: 10.1073/pnas.0804812105 114 SongL.YangJ.KongW.LiuY.LiuS.SuL
[PMID: 14879083] PubMed record related to this compound for laboratory literature review
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