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trial 2: N = 32) demonstrated that there were no clinically relevant effects of oral semaglutide (20 mg) on the plasma concentration-time curve (AUC) and maximum plasma concentration ( C max ) for the antihypertensive drug lisinopril (20 mg single dose [trial 1]), the anticoagulant agent warfarin (25 mg single dose [trial 1]), or digoxin (500 g [trial 2]) [42]

They went away for a while and then came back in full force in the 1990s