The metabolism and clearance of both components may be affected by significant liver disease, and patients with severe hepatic impairment should be monitored closely if treatment is deemed necessary
However, when the reduced affinity was accounted for, exendin-phe1 and, to a lesser extent, lixi-phe1, were more efficiently coupled to cAMP production than the -asp3 versions (Figure 6C)
Importantly, the compound has shown a good safety record, with very few side effects reported
Comparative pharmacology versus the related research compounds listed below, in matched-vehicle preclinical models
ALTERNATIVES TO BIRTH CONTROL PILLS Patients concerned about interactions between GLP-1 medications and birth control should talk to their care providers to make sense of manufacturer recommendations and learn about alternatives to oral contraceptives