Its common to experience mild side effects, such as nausea or digestive discomfort, during the initial weeks of semaglutide treatment
Several evidence-based strategies can help minimize bloating while taking semaglutide
Roughly 12.7% of users are diagnosed with a nutritional deficiency within six months of starting treatment, and that climbs to 22.4% by the 12-month mark, according to a 2025 claims analysis of more than 460,000 GLP-1 users [3]
The quieting is also where the headline results come from: in the STEP-1 trial, 1,961 adults on weekly semaglutide lost an average of 14.9% of body weight over 68 weeks, and in SURMOUNT-1, tirzepatide's top dose averaged 20.9% over 72 weeks - effects built in large part on appetite, and its chatter, turning down
Whole-cell T4 is marketed as RGN-352 in the clinical development of RegeneRx for corneal diseases