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A common pattern involves using higher doses (2mg daily) during the first cycle, then transitioning to maintenance doses (1mg 2-3x weekly) for subsequent cycles

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Mechanism of action: Amlodipine: Amlodipine is a dihydropyridine calcium channel blocker that inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells

Other practices that have been documented include the use of depleted milk thistle extracts, which are cheap and are of poor quality, so this is clearly an example of economically-motivated adulteration