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Aging Renal or hepatic impairment (and other pre-existing medical conditions) Alcohol use Concurrent use of certain medications Malnutrition Note : Always read dosing instructions and warnings on every medication

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[11] In fact, some studies in animals suggest that even mild biotin deficiency could be harmful to the developing fetus, so the goal is to ensure adequate, but not excessive, biotin

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4) Tendon and Connective-Tissue Support A human-focused translational review 8 reports IGF-1 stimulates collagen expression and matrix synthesis in human tendon cellderived constructs, supporting the concept of stronger, better-organized connective tissue during rehabilitation

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