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mtDNA, enriched in unmethylated CpG motifs, activates pattern recognition receptors (PRRs) including cGAS and TLR9, amplifying inflammatory responses (Newman and Shadel, 2023)

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That distinction can matter when reading literature or analytical records

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Superoxide dismutases: dual roles in controlling ROS damage and regulating ROS signaling

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10.1038/s41577-019-0178-8 116 TsukimuraN.YamadaM.AitaH.HoriN.YoshinoF.Chang-Il LeeM.et al (2009)

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