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There is a consensus that GPX and GCL are the two enzymes in the glutathione pathway that are upregulated by estradiol
Sousa-Victor, P., Garca-Prat, L
Zhang Y, Cai T, Yuan M, Li Z, Jin R, Ren Z, Qin Y, Yu C, Cai Y, Shu R, He S, Li J, Wong ACN, Wan H (2023) Microbiome variation correlates with the insecticide susceptibility in different geographic strains of a significant agricultural pest, Nilaparvata lugens
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Additionally, decreased production of ceramides may potentially harm gut epithelial cells by reducing LPS hydrolysis and increase gut permeability [28]
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