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For individuals experiencing chronic fatigue or low energy, evaluating B12 deficiency can be a crucial step
For people whose deficiency is caused by an absorption problem, injections are the more dependable option
Zuri Hemphill-Bryant, an Atlanta-based OB-GYN, tells Romper via email
More from the series Subscribe: Apple Podcasts Spotify Injectable peptide therapy, a controversial wellness trend that caught fire online in 2025, shows no signs of slowing down in 2026, despite an overwhelming lack of safety data
The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool was used to assess the certainty of the evidence for the two primary biochemical outcomesserum vitamin B12 concentration increase and homocysteine reductionacross all included studies, and separately for randomised controlled trials (RCTs) and observational studies
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