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doi: 10.1111/and.v51.10 102 MajzoubAAgarwalA
These patients represent a very small proportion of the population (approximately 1 of 200,000 individuals in the world) and have very severe hyperhomocysteinemia that can reach 400 mol/L
demonstrated that 8-oxoG in the telomeric region has a dual role, either hindering telomerase-mediated elongation when incorporated as 8-oxodGTP or promoting telomerase activity by destabilizing G-quadruplex structures when preexisting in telomere DNA
Signal Transduction and Targeted Therapy, 2 (1), 1-9
PMC 2175300
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