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Notably, urinary metabolomic profiling demonstrated significantly elevated Gly excretion in CD patients compared to HCs, potentially indicating altered AAs metabolism characteristic of the disease (Bertini et al

Treatment may include CBT-I, sleep schedule support, mental health care, medication review, sleep apnea screening, circadian rhythm interventions, or other individualized options

The VA-IMPACT trial is attempting to fill this gap by evaluating cardiovascular outcomes in patients with pre-diabetes and established CVD treated with metformin versus placebo (NCT02915198)

Each 0.1 mL (10 units on an insulin syringe) would then deliver 0.5 mg