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The purity of isolated RNA will be assessed using the DeNovix DS-11 FX+ spectrophotometer (DeNovix Inc., Wilmington, USA), and its integrity will be determined on an Agilent 2100 Bioanalyzer using the RNA 6000 Nano LabChip kit (Agilent, Santa Clara, USA)
It is broken down into smaller pieces called amino acids by various tissues in the body
Whilst attractive as a theory, it should, nevertheless, be borne in mind that the majority of the studies cited above have been carried out in rodents or have examined isolated islets/-cells under in vitro or ex vivo conditions, and whether a local pancreatic DPP-4/GLP-1 system plays an important role in normal human physiology or in the pharmacological effect of DPP-4 inhibitors is not clear
Steffen BT, Lees SJ, Booth FW
Experimental research models
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