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Exenatide and lixisenatide are derived from exogenous Gila monster venom and have an exendin-4 backbone, whereas the remaining 4 commercially available GLP1RAs are modifications of endogenous GLP1 (52)

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Importantly, no cases of MTC have been causally linked to GLP-1 RA use in humans to date, and rodent C-cells are known to be more sensitive to GLP-1 stimulation than human C-cells

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