In contrast, a pooled analysis of clinical trials reporting separate CV events rates in patients with T2D and CKD did not find GLP1-RA to be associated with a reduction in composite CV event rates [76]
And it can cross the blood-rain barrier, reduce inflammation and oxidative stress, and protect synapses and neurons, showing neuroprotective effects in animal models of AD and PD (Hong et al., 2024)
[15] The therapy is used off-label based on emerging science and clinical experience
In vitro prophylactic injection of IL-22 can significantly reduce the expression of pro-inflammatory factors IL-6, IL-1, TNF-, and the liver necrosis area and increase the expression of hepatocyte proliferation marker Ki-67, suggesting that IL-22 through promoting hepatocyte proliferation mediates hepatoprotective functions and has the therapeutic potential in AILI [174]
These physiological differences mean that weight management interventions may interact with female biology in ways that require specific consideration