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Most gastrointestinal side effects are classified as mild to moderate in severity and tend to occur primarily during dose escalation periods

M., Zschocke, J., Christensen, E., Burgard, P., and Hoffmann, G

Endoplasmic reticulum stress is a state in which the accumulation of unfolded/misfolded proteins is accelerated after ER disorders caused by a variety of physiological and pathological conditions