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Dispose of materials per institutional and regulatory waste requirements

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Start with tirzepatide monotherapy, titrate to therapeutic dose (12.515mg weekly), allow 1620 weeks to reach plateau, then reassess

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During tissue granulation, fibroblasts form a bed of collagen by transforming into the myofibroblast phenotype, with an augmented alpha-smooth muscle actin (-SMA) cytoskeleton, which is critical for promoting Wound Healing (van de Water et al., 2013)