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RSL-3 blocks GPX4, which increases the levels of ROS and malondialdehyde (MDA) inside cells and promotes ferroptosis by blocking the SLC7A11/GSH/GPX4 pathway (73)

Ezzikouri, S

As an experimental system we used a human BBB co-culture model improved by cARLA

In contrast, non-enzymatic antioxidants, primarily obtained from external sources (e.g., vitamin C and E, coenzyme Q, carotenes, and trace elements), play roles in neutralizing ROS, oxidation prevention, and enzymatic function

Conclusion As we navigate the journey of pregnancy and motherhood, understanding the safety and efficacy of supplements like glutathione becomes paramount