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A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient
Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase
Laboratory synthesis replicates that sequence to produce a stable compound for study
2008;6:e182
(2009a)
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