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Significant prior efforts across the pharmaceutical industry have failed to identify potent and efficacious small-molecule agonists of the GLP-1R ( 15, 16 )

Following the predefined inclusion and exclusion criteria, 36 studies were included in this systematic review and underwent qualitative analysis

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In November 2025, the Trump administration announced TrumpRx, a federal direct purchasing platform using tariff threats to extract Most Favored Nation (MFN) pricing from pharmaceutical manufacturers & bringing the cost of GLP-1s like Ozempic down to $350/month for cash payers (from $1,350/month)

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