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ACAT1 , (B) SREBP-2 , (C) HMGCR , (D) SQLE , (E) LXR , (F) CYP7A1 , (G) LDLR , (H) PCSK9 , (I) SR-B1 , and (J) ABCA1 genes were analyzed by quantitative real-time polymerase chain reaction and normalized to that of the ACTB gene

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STEP and SELECT Trial Data, What Researchers Are Working From The pivotal STEP 1 trial (Wilding et al., NEJM 2021, NCT03548935) enrolled 1,961 adults with obesity (no T2D) over 68 weeks at the 2.4mg/week dose

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