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Actually, sodium delivery to the macula densa could be increased by SGLT2 inhibitors, the increased sodium delivery is sensed as an increase in circulating volume at the level of the juxtaglomerular apparatus, resulting in a constriction of afferent renal arterioles, a decrease in intraglomerular pressure and a reversible decrease in single nephron GFR [18, 32]

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That structure is far easier to maintain with a sublingual strip than with repeated clinic visits or self-administered injections