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Pillars 13 , 100162 (2025)
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The problem is a data disconnect because the pharmacy and medical claims tell us that GLP-1 usage is soaring, but they dont tell us which patients benefit, which patients fail, and why
No effects were seen when glucose was not administered, compatible with the idea that DPP-4 inhibition exerts an anti-hyperglycaemic effect by preventing degradation of endogenously released GLP-1 (26), subsequent studies in glucose-intolerant rodent models did show that the improved glycaemic control following in vivo DPP-4 inhibition was associated with enhanced intact GLP-1 responses to glucose challenges (2729)
Women constituted a minority of the prevalent patients dispensed a GLP-1 RA between 2019 and 2022
