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Unlike small-molecule drugs such as aspirin or ibuprofen, which can tolerate wide temperature swings without losing effectiveness, peptides are proteins with complex three-dimensional structures that depend on precise folding to function
PMID 42492375
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doi:10.3390/nu15020261
Furthermore, intravenous glutathione (12 injections of 1,200 mg) showed no benefit for skin lightening compared to placebo in a Pakistani study (Zubair et al., J Pakistan Assoc Dermatol, 2016) [64]
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