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In populations with added comorbidities, results are lower: TRIUMPH-2 (obesity + diabetes) showed 20.8%, TRIUMPH-3 (obesity + cardiovascular disease) showed 22.6%, and TRANSCEND-T2D-1 (diabetes-specific, 40 weeks) showed 16.8% all consistent with patterns seen across the GLP-1 drug class, where comorbidities reduce achievable weight loss
The approval is based on the OASIS trial programme and the SELECT trial2
The study of endogenous GLP-1 production in joints requires more research because this field remains insufficiently explored
As time goes on and vitamin C levels in the body fall even further, the symptoms of deficiency would start to appear
Take a look at Ozempics before and after photos
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