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These two categories are not interchangeable

PFIC are paediatric manifestations, but the same variants causing PFIC can also cause cholestasis with a later paediatric onset or adult-onset cholestatic disease (AOCD)

We are now beginning to reach the stage of functionally understanding the molecular mechanisms, defining exactly which neuronal populations respond to specific nutritional and related signals, and how they pass on that information

The introduction of new therapiesparticularly those with novel mechanisms of action or broader symptom coveragemay fragment prescriber preferences and intensify competition for patient share

Sources US Food and Drug Administration