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Science (1993) 259(5091):8791.10.1126/science.7678183 11 ClavelTDesmarchelierCHallerDGrardPRohnSLepagePet alIntestinal microbiota in metabolic diseases: from bacterial community structure and functions to species of pathophysiological relevance

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Of course, unless several other people in your household will be taking the supplement, you'll probably want an interval somewhere in the middle of that range, as a single user can get three months of use from a single bottle