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Importantly, functional B12 deficiency can sometimes coexist with high total B12 levels, especially in kidney disease, and may require additional testing with methylmalonic acid (MMA) or holotranscobalamin if deficiency is suspected clinically
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Chromatographic and mass spectrometric parameters of this screening method are summarized in the Table 1
Before researchers can conduct meaningful evaluations, they often begin with characterization studies involving 5-Amino-1MQ and other specialized research compounds
MHRA classification guide Human Medicines Regulations 2012, Regulation 279
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