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Timeline and Patterns Fatigue from GLP-1 medications typically follows these patterns: Weeks 1-2: Initial fatigue as your body adjusts to appetite changes Weeks 2-4: May peak during dose titration periods (the planned, gradual increases in medication dosage used to help your body adjust safely to a new treatment) Weeks 4-8: Gradual improvement as eating patterns stabilise 8+ weeks: Most people experience significant improvement Common triggers for fatigue episodes: Starting treatment or increasing doses Periods of very low food intake Rapid weight loss (more than 1-2 pounds per week) Illness or stress Changes in exercise routine How to Manage Fatigue While Taking GLP-1s If tiredness is affecting your day-to-day life, try these simple, practical strategies: 1

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