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To be avoided in case of chronic liver disease, seizures/epilepsy

Glutathione depletion is linked with Th2 polarization in mice with a retrovirus-induced immunodeficiency syndrome, murine AIDS: role of proglutathione molecules as immunotherapeutics

However, special care must be used when using lemon juice in the sun as it can cause a reaction on the skin and actually cause or worsen the appearance of existing skin hyperpigmentation