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1 Excess adipose tissue can lead to multiple obesity-related complications, including metabolic complications (e.g., type 2 diabetes, hypertension, and dyslipidemia), mechanical complications (e.g., obstructive sleep apnea and osteoarthritis), and psychological complications (e.g., depression and anxiety), with a negative effect on physical function and health-related quality of life, and reduced life expectancy

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However, since no direct studies support the use of B12 injections for weight loss, more research is warranted

Dec 15 2020;333:127459

[Mechanism of delta-sleep inducing peptide geroprotective activity]