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High dose vitamin C is generally synergistic with glutathione (vitamin C actually recycles oxidized glutathione back to its active form), but mega doses above 2,000 mg taken at the same moment as oral glutathione can compete for absorption in the gut

Rizzuto R, De Stefani D, Raffaello A, Mammucari C

Mani S, Li H, Yang G, Wu L, Wang R (2015) Deficiency of cystathionine gamma-lyase and hepatic cholesterol accumulation during mouse fatty liver development

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Studies supplemented NAC along with other interventions